The Warburg effect is known as the hyperactive glycolysis that provides the energy needed for rapid growth and proliferation in most tumor cells even under the big boys wetsuit condition of sufficient oxygen.This metabolic pattern can lead to a large accumulation of lactic acid and intracellular acidification, which can affect the growth of tumor c

Extended water intakes are structures established at river sides to divert water for multiple uses and purposes.Previous studies have only focused on extending the intake to a sufficient water depth for ensuring permanent abstraction.They used physical and numerical models to predict the trend of the site riverbed morphological changes for identify

BackgroundThe first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC).However, 3.26/3VR partial patients did not respond to the combination treatment.The roles of dendritic cells (DCs) and macrophages in this comb

Numerous developing countries recognize the latent possibilities of their natural resources for tourism growth and sustainability.Community based tourism initiatives are essentially cooperative actions by clusters of people in a community through which some small to medium scale homegrown tourism industry can be developed.There is thus a popular vi